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KMID : 0903519940370060498
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Journal of the Korean Society of Agricultural Chemistry and Biotechnology
1994 Volume.37 No. 6 p.498 ~ p.502
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Structure Determinatin of Glucosyltransferase Inhibitors from Cacao Bean Husk
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Abstract
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For glucosyltransferase(GTase) inhibitors, two flavan-3-ols were isolated from Theobroma cacao beam husk. They showed positive reaction with anisadehyde-H₂SO₄ solution, FeCl₃ to be confirmed as dimeric flavan-3-ols on TLC and were identified as procyanidin B-1 [(-)-epicatechin-(4β→8)-catechin] and procyanidin B-3 [(+)-catechin-(4β→8)-catechin by spectroscopic analysis. Their inhibitory effect on glucosyltranaferase activity was also investigated and procyanidin B-1 showed 50% inhibition at 0.3 mM. They inhibited on the glucosyltransferasa noncompetitively and dimeric flavan-3-ol containing (-)-epicatechin had higer inhibitory activity.
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KEYWORD
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